[HTML][HTML] Role of nuclear factor κB in multiple sclerosis and experimental autoimmune encephalomyelitis

Y Yue, S Stone, W Lin - Neural regeneration research, 2018 - journals.lww.com
The transcription factor nuclear factor κB (NF-κB) plays major roles in inflammatory diseases
through regulation of inflammation and cell viability. Multiple sclerosis (MS) is a chronic
inflammatory demyelinating and neurodegenerative disease of the central nervous system
(CNS). It has been shown that NF-κB is activated in multiple cell types in the CNS of MS
patients, including T cells, microglia/macrophages, astrocytes, oligodendrocytes, and
neurons. Interestingly, data from animal model studies, particularly studies of experimental …