[HTML][HTML] CD83 expression influences CD4+ T cell development in the thymus

Y Fujimoto, LL Tu, AS Miller, C Bock, M Fujimoto… - Cell, 2002 - cell.com
Y Fujimoto, LL Tu, AS Miller, C Bock, M Fujimoto, C Doyle, DA Steeber, TF Tedder
Cell, 2002cell.com
T lymphocyte selection and lineage commitment in the thymus requires multiple signals.
Herein, CD4+ T cell generation required engagement of CD83, a surface molecule
expressed by thymic epithelial and dendritic cells. CD83-deficient (CD83−/−) mice had a
specific block in CD4+ single-positive thymocyte development without increased CD4+
CD8+ double-or CD8+ single-positive thymocytes. This resulted in a selective 75%–90%
reduction in peripheral CD4+ T cells, predominantly within the naive subset. Wild-type …
Abstract
T lymphocyte selection and lineage commitment in the thymus requires multiple signals. Herein, CD4+ T cell generation required engagement of CD83, a surface molecule expressed by thymic epithelial and dendritic cells. CD83-deficient (CD83−/−) mice had a specific block in CD4+ single-positive thymocyte development without increased CD4+CD8+ double- or CD8+ single-positive thymocytes. This resulted in a selective 75%–90% reduction in peripheral CD4+ T cells, predominantly within the naive subset. Wild-type thymocytes and bone marrow stem cells failed to differentiate into mature CD4+ T cells when transferred into CD83−/− mice, while CD83−/− thymocytes and stem cells developed normally in wild-type mice. Thereby, CD83 expression represents an additional regulatory component for CD4+ T cell development in the thymus.
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