The soluble form of CD83 is present at elevated levels in a number of hematological malignancies
BD Hock, LF Haring, A Steinkasserer, KG Taylor… - Leukemia research, 2004 - Elsevier
Recombinant forms of soluble CD83 (sCD83) inhibit anti-tumor responses. In this analysis of
circulating sCD83 levels we report that although> 95% of acute myeloid leukemia (AML) and
multiple myeloma (MM) patients have normal or only weakly elevated sCD83 levels, 20% of
chronic lymphocytic leukemia (CLL) and 5/7 mantle cell lymphoma (MCL) patients have
significantly elevated levels (> 1ng/ml). Isolated CLL cells both weakly expressed membrane
CD83 (mCD83), and released sCD83 during in vitro culture. We conclude that malignant …
circulating sCD83 levels we report that although> 95% of acute myeloid leukemia (AML) and
multiple myeloma (MM) patients have normal or only weakly elevated sCD83 levels, 20% of
chronic lymphocytic leukemia (CLL) and 5/7 mantle cell lymphoma (MCL) patients have
significantly elevated levels (> 1ng/ml). Isolated CLL cells both weakly expressed membrane
CD83 (mCD83), and released sCD83 during in vitro culture. We conclude that malignant …
