[HTML][HTML] Murine CD83-positive T cells mediate suppressor functions in vitro and in vivo

S Kreiser, J Eckhardt, C Kuhnt, M Stein, L Krzyzak… - Immunobiology, 2015 - Elsevier
Abstract The CD83 molecule (CD83) is a well-known surface marker present on mature
dendritic cells (mDC). In this study, we show that CD83 is also expressed on a subset of T
cells which mediate regulatory T cell (Treg)-like suppressor functions in vitro and in vivo.
Treg-associated molecules including CD25, cytotoxic T lymphocyte antigen-4 (CTLA-4),
glucocorticoid-induced TNFR family-related gene (GITR), Helios and neuropilin-1 (NRP-1)
as well as forkhead box protein 3 (FOXP3) were specifically expressed by these CD83+ T …