CNI-1493 mediated suppression of dendritic cell activation in vitro and in vivo
E Zinser, N Turza, A Steinkasserer - Immunobiology, 2004 - Elsevier
The tetravalent guanylhydrazone CNI-1493 (CNI-1493) has been shown to inhibit
macrophage activation, reduce systemic inflammation as well as proinflammatory cytokine
production. Here we report for the first time that CNI-1493 also influences the biology of
dendritic cells (DC). In order to become potent T cell stimulators of DC have to mature.
Interestingly, when CNI-1493 was added to the maturation stimulus the expression of a
typical DC-maturation marker ie CD83 was reduced. Subsequent functional in vitro analyses …
macrophage activation, reduce systemic inflammation as well as proinflammatory cytokine
production. Here we report for the first time that CNI-1493 also influences the biology of
dendritic cells (DC). In order to become potent T cell stimulators of DC have to mature.
Interestingly, when CNI-1493 was added to the maturation stimulus the expression of a
typical DC-maturation marker ie CD83 was reduced. Subsequent functional in vitro analyses …
