Inhibition of IL-17–committed T cells in a murine psoriasis model by a vitamin D analogue
N Kusuba, A Kitoh, T Dainichi, T Honda… - Journal of Allergy and …, 2018 - Elsevier
Background A better understanding of the means by which topical vitamin D analogues
exert their therapeutic effect on psoriasis is of theoretical and practical importance. Objective
We sought to clarify whether and how the topical vitamin D analogue calcipotriol (CAL)
controls the IL-17A–mediated pathogenesis of murine psoriasis-like dermatitis in vivo.
Methods Psoriasis-like dermatitis was induced by the topical application of an imiquimod
(IMQ)–containing cream on the murine ear for 4 to 6 consecutive days. For topical CAL …
exert their therapeutic effect on psoriasis is of theoretical and practical importance. Objective
We sought to clarify whether and how the topical vitamin D analogue calcipotriol (CAL)
controls the IL-17A–mediated pathogenesis of murine psoriasis-like dermatitis in vivo.
Methods Psoriasis-like dermatitis was induced by the topical application of an imiquimod
(IMQ)–containing cream on the murine ear for 4 to 6 consecutive days. For topical CAL …