Patients with cystic fibrosis have inducible IL-17+ IL-22+ memory cells in lung draining lymph nodes
YR Chan, K Chen, SR Duncan, KL Lathrop… - Journal of allergy and …, 2013 - Elsevier
BACKGROUND: IL-17 is an important cytokine signature of the TH differentiation pathway
TH17. This T-cell subset is crucial in mediating autoimmune disease or antimicrobial
immunity in animal models, but its presence and role in human disease remain to be
completely characterized. OBJECTIVE: We set out to determine the frequency of TH17 cells
in patients with cystic fibrosis (CF), a disease in which there is recurrent infection with known
pathogens. METHODS: Explanted lungs from patients undergoing transplantation or organ …
TH17. This T-cell subset is crucial in mediating autoimmune disease or antimicrobial
immunity in animal models, but its presence and role in human disease remain to be
completely characterized. OBJECTIVE: We set out to determine the frequency of TH17 cells
in patients with cystic fibrosis (CF), a disease in which there is recurrent infection with known
pathogens. METHODS: Explanted lungs from patients undergoing transplantation or organ …