[HTML][HTML] BET bromodomains regulate transforming growth factor-β-induced proliferation and cytokine release in asthmatic airway smooth muscle
Airway smooth muscle (ASM) mass is increased in asthma, and ASM cells from patients with
asthma are hyperproliferative and release more IL-6 and CXCL8. The BET (bromo-and extra-
terminal) family of proteins (Brd2, Brd3, and Brd4) govern the assembly of histone
acetylation-dependent chromatin complexes. We have examined whether they modulate
proliferation and cytokine expression in asthmatic ASM cells by studying the effect of BET
bromodomain mimics JQ1/SGCBD01 and I-BET762. ASM cells from healthy individuals and …
asthma are hyperproliferative and release more IL-6 and CXCL8. The BET (bromo-and extra-
terminal) family of proteins (Brd2, Brd3, and Brd4) govern the assembly of histone
acetylation-dependent chromatin complexes. We have examined whether they modulate
proliferation and cytokine expression in asthmatic ASM cells by studying the effect of BET
bromodomain mimics JQ1/SGCBD01 and I-BET762. ASM cells from healthy individuals and …