[HTML][HTML] BET bromodomains regulate transforming growth factor-β-induced proliferation and cytokine release in asthmatic airway smooth muscle

MM Perry, AL Durham, PJ Austin, IM Adcock… - Journal of Biological …, 2015 - ASBMB
Airway smooth muscle (ASM) mass is increased in asthma, and ASM cells from patients with
asthma are hyperproliferative and release more IL-6 and CXCL8. The BET (bromo-and extra-
terminal) family of proteins (Brd2, Brd3, and Brd4) govern the assembly of histone
acetylation-dependent chromatin complexes. We have examined whether they modulate
proliferation and cytokine expression in asthmatic ASM cells by studying the effect of BET
bromodomain mimics JQ1/SGCBD01 and I-BET762. ASM cells from healthy individuals and …