Immune complexes inhibit IL-1 secretion and inflammasome activation

JR Janczy, C Ciraci, S Haasken, Y Iwakura… - The Journal of …, 2014 - journals.aai.org
JR Janczy, C Ciraci, S Haasken, Y Iwakura, AK Olivier, SL Cassel, FS Sutterwala
The Journal of Immunology, 2014journals.aai.org
IgG immune complexes have been shown to modify immune responses driven by APCs in
either a pro-or anti-inflammatory direction depending upon the context of stimulation.
However, the ability of immune complexes to modulate the inflammasome-dependent innate
immune response is unknown. In this study, we show that IgG immune complexes suppress
IL-1α and IL-1β secretion through inhibition of inflammasome activation. The mechanism by
which this inhibition occurs is via immune complex ligation of activating FcγRs, resulting in …
Abstract
IgG immune complexes have been shown to modify immune responses driven by APCs in either a pro-or anti-inflammatory direction depending upon the context of stimulation. However, the ability of immune complexes to modulate the inflammasome-dependent innate immune response is unknown. In this study, we show that IgG immune complexes suppress IL-1α and IL-1β secretion through inhibition of inflammasome activation. The mechanism by which this inhibition occurs is via immune complex ligation of activating FcγRs, resulting in prevention of both activation and assembly of the inflammasome complex in response to nucleotide-binding domain leucine-rich repeat (NLR) P3, NLRC4, or AIM2 agonists. In vivo, administration of Ag in the form of an immune complex during priming of the immune response inhibited resultant adaptive immune responses in an NLRP3-dependent model of allergic airway disease. Our data reveal an unexpected mechanism regulating CD4+ T cell differentiation, by which immune complexes suppress inflammasome activation and the generation of IL-1α and IL-1β from APCs, which are critical for the Ag-driven differentiation of CD4+ T cells.
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