Peanut-specific type 1 regulatory T cells induced in vitro from allergic subjects are functionally impaired
L Pellerin, JA Jenks, S Chinthrajah… - Journal of Allergy and …, 2018 - Elsevier
Background Peanut allergy (PA) is a life-threatening condition that lacks regulator-approved
treatment. Regulatory T type 1 (TR 1) cells are potent suppressors of immune responses and
can be induced in vivo upon repeated antigen exposure or in vitro by using tolerogenic
dendritic cells. Whether oral immunotherapy (OIT) leads to antigen-specific TR 1 cell
induction has not been established. Objectives We sought to determine whether peanut-
specific TR 1 cells can be generated in vitro from peripheral blood of patients with PA at …
treatment. Regulatory T type 1 (TR 1) cells are potent suppressors of immune responses and
can be induced in vivo upon repeated antigen exposure or in vitro by using tolerogenic
dendritic cells. Whether oral immunotherapy (OIT) leads to antigen-specific TR 1 cell
induction has not been established. Objectives We sought to determine whether peanut-
specific TR 1 cells can be generated in vitro from peripheral blood of patients with PA at …