Allergic dysregulation and hyperimmunoglobulinemia E in Foxp3 mutant mice
W Lin, N Truong, WJ Grossman, D Haribhai… - Journal of Allergy and …, 2005 - Elsevier
BACKGROUND: Regulatory T cells have been proposed to play an important role in
regulating allergic inflammation. The transcription factor Foxp3 is a master switch gene that
controls the development and function of natural and adaptive CD4+ CD25+ regulatory T
(TR) cells. In human subjects loss-of-function Foxp3 mutations trigger lymphoproliferation,
autoimmunity, and intense allergic inflammation in a disease termed immune dysregulation
polyendocrinopathy enteropathy–X-linked syndrome. OBJECTIVE: We sought to examine …
regulating allergic inflammation. The transcription factor Foxp3 is a master switch gene that
controls the development and function of natural and adaptive CD4+ CD25+ regulatory T
(TR) cells. In human subjects loss-of-function Foxp3 mutations trigger lymphoproliferation,
autoimmunity, and intense allergic inflammation in a disease termed immune dysregulation
polyendocrinopathy enteropathy–X-linked syndrome. OBJECTIVE: We sought to examine …