[HTML][HTML] IL-27 suppresses type 2 immune responses in vivo via direct effects on group 2 innate lymphoid cells
T Mchedlidze, M Kindermann, AT Neves… - Mucosal …, 2016 - Elsevier
Group 2 innate lymphoid cells (ILC2) were recently characterized by their ability to produce
significant amounts of type-2 signature cytokines and drive central beneficial and
pathological features of type-2 immune responses. Although factors such as IL-33 and IL-25
were shown to have ILC2 activating capacity, it is not well understood, how ILC2 responses
are regulated in vivo. Here we provide compelling evidence that IL-27-signalling directly
inhibits ILC2 responses and reveal a novel mechanism for negative regulation of the innate …
significant amounts of type-2 signature cytokines and drive central beneficial and
pathological features of type-2 immune responses. Although factors such as IL-33 and IL-25
were shown to have ILC2 activating capacity, it is not well understood, how ILC2 responses
are regulated in vivo. Here we provide compelling evidence that IL-27-signalling directly
inhibits ILC2 responses and reveal a novel mechanism for negative regulation of the innate …