Therapeutic approaches to allergy and autoimmunity based on FoxP3+ regulatory T-cell activation and expansion
M Miyara, K Wing, S Sakaguchi - Journal of allergy and clinical immunology, 2009 - Elsevier
Forkhead box protein 3–positive regulatory T (Treg) cells are indispensable for the
maintenance of self-tolerance and immune homeostasis. They can also be exploited for the
treatment of immunologic diseases, including autoimmune diseases and allergy, by way of
activating and expanding antigen-specific Treg cells in vivo. Cell therapy with in vitro
activated and expanded Treg cells can be another therapeutic modality. The feasibility of
such Treg cell–based therapeutic strategies is discussed based on recent advances in our …
maintenance of self-tolerance and immune homeostasis. They can also be exploited for the
treatment of immunologic diseases, including autoimmune diseases and allergy, by way of
activating and expanding antigen-specific Treg cells in vivo. Cell therapy with in vitro
activated and expanded Treg cells can be another therapeutic modality. The feasibility of
such Treg cell–based therapeutic strategies is discussed based on recent advances in our …
