The immunobiology of IL-27
Like many cytokines, IL-27 has pleiotropic properties that can limit or enhance ongoing
immune responses depending on context. Thus, under certain circumstances, IL-27 can
promote TH1 differentiation and has been linked to the activation of CD8+ T cells and
enhanced humoral responses. However, IL-27 also has potent inhibitory properties and
mice that lack IL-27 mediated signaling develop exaggerated inflammatory responses in the
context of infection or autoimmunity. This chapter reviews in depth the biology of IL-27 …
immune responses depending on context. Thus, under certain circumstances, IL-27 can
promote TH1 differentiation and has been linked to the activation of CD8+ T cells and
enhanced humoral responses. However, IL-27 also has potent inhibitory properties and
mice that lack IL-27 mediated signaling develop exaggerated inflammatory responses in the
context of infection or autoimmunity. This chapter reviews in depth the biology of IL-27 …