Role of fatty acid elongases in determination of de novo synthesized monounsaturated fatty acid species [S]
CD Green, CG Ozguden-Akkoc, Y Wang, DB Jump… - Journal of lipid …, 2010 - ASBMB
Enhanced production of monounsaturated fatty acids (FA) derived from carbohydrate-
enriched diets has been implicated in the development of obesity and insulin resistance.
The FA elongases Elovl-5 and Elovl-6 are regulated by nutrient and hormone status, and
have been shown using intact yeast and mammalian microsome fractions to be involved in
the synthesis of monounsaturated FAs (MUFA). Herein, targeted knockdown and
overexpression of Elovl-5 or Elovl-6 was used to determine their roles in de novo synthesis …
enriched diets has been implicated in the development of obesity and insulin resistance.
The FA elongases Elovl-5 and Elovl-6 are regulated by nutrient and hormone status, and
have been shown using intact yeast and mammalian microsome fractions to be involved in
the synthesis of monounsaturated FAs (MUFA). Herein, targeted knockdown and
overexpression of Elovl-5 or Elovl-6 was used to determine their roles in de novo synthesis …
