[HTML][HTML] The role of microRNA-155/liver X receptor pathway in experimental and idiopathic pulmonary fibrosis
M Kurowska-Stolarska, MK Hasoo, DJ Welsh… - Journal of Allergy and …, 2017 - Elsevier
Background Idiopathic pulmonary fibrosis (IPF) is progressive and rapidly fatal. Improved
understanding of pathogenesis is required to prosper novel therapeutics. Epigenetic
changes contribute to IPF; therefore, microRNAs may reveal novel pathogenic pathways.
Objectives We sought to determine the regulatory role of microRNA (miR)-155 in the
profibrotic function of murine lung macrophages and fibroblasts, IPF lung fibroblasts, and its
contribution to experimental pulmonary fibrosis. Methods Bleomycin-induced lung fibrosis in …
understanding of pathogenesis is required to prosper novel therapeutics. Epigenetic
changes contribute to IPF; therefore, microRNAs may reveal novel pathogenic pathways.
Objectives We sought to determine the regulatory role of microRNA (miR)-155 in the
profibrotic function of murine lung macrophages and fibroblasts, IPF lung fibroblasts, and its
contribution to experimental pulmonary fibrosis. Methods Bleomycin-induced lung fibrosis in …