Fibrinogen is a pleiotropic blood protein that regulates coagulation, inflammation and tissue
repair. Fibrinogen extravasates in the nervous system after injury or disease associated with
vascular damage or blood–brain barrier (BBB) disruption. Fibrinogen is not merely a marker
of BBB disruption, but plays a causative role in neurologic disease as a potent inducer of
inflammation and an inhibitor of neurite outgrowth. Fibrinogen mediates functions in the
nervous system as a ligand for cell-specific receptors. In microglia, fibrinogen mediates …