Significance of early intra-alveolar fibrotic lesions and integrin expression in lung biopsy specimens from patients with idiopathic pulmonary fibrosis
Y Fukuda, F Basset, VJ Ferrans, N Yamanaka - Human pathology, 1995 - Elsevier
To study the pulmonary structural remodeling in idiopathic pulmonary fibrosis (IPF),
ultrastructural, immunohistochemical, and light microscopic morphometric observations
were made on 11 pulmonary biopsy specimens from patients with IPF. The morphometric
study was done using sequentially cut tissue sections stained for keratin-alcian blue periodic
acid-Schiff (PAS), fibronectin, and type IV collagen-alcian blue PAS. Most of the early fibrotic
lesions, which were alcian blue-and fibronectin-positive, were intra-alveolar in location. Intra …
ultrastructural, immunohistochemical, and light microscopic morphometric observations
were made on 11 pulmonary biopsy specimens from patients with IPF. The morphometric
study was done using sequentially cut tissue sections stained for keratin-alcian blue periodic
acid-Schiff (PAS), fibronectin, and type IV collagen-alcian blue PAS. Most of the early fibrotic
lesions, which were alcian blue-and fibronectin-positive, were intra-alveolar in location. Intra …
