Pathobiology of severe asthma
HE Trejo Bittar, SA Yousem… - Annual Review of …, 2015 - annualreviews.org
Severe asthma (SA) afflicts a heterogeneous group of asthma patients who exhibit poor
responses to traditional asthma medications. SA patients likely represent 5–10% of all
asthma patients; however, they have a higher economic burden when compared with milder
asthmatics. Considerable research has been performed on pathological pathways and
structural changes associated with SA. Although limitations of the pathological approaches,
ranging from sampling, to quantitative assessments, to heterogeneity of disease, have …
responses to traditional asthma medications. SA patients likely represent 5–10% of all
asthma patients; however, they have a higher economic burden when compared with milder
asthmatics. Considerable research has been performed on pathological pathways and
structural changes associated with SA. Although limitations of the pathological approaches,
ranging from sampling, to quantitative assessments, to heterogeneity of disease, have …
