IL-13 receptor α 2: A regulator of IL-13 and IL-4 signal transduction in primary human fibroblasts
AL Andrews, T Nasir, F Bucchieri, JW Holloway… - Journal of allergy and …, 2006 - Elsevier
BACKGROUND: IL-13 and IL-4 share many functional properties as a result of their use of a
common receptor complex comprising IL-13 receptor α 1 (IL-13Rα1) and IL-4 receptor α (IL-
4Rα). The nonsignaling receptor IL-13 receptor α 2 (IL-13Rα2) binds IL-13 with high affinity
and specificity and is believed to be a decoy receptor for IL-13. OBJECTIVE: We sought to
examine the inhibitory effects of soluble and membrane-bound IL-13Rα2 on IL-13–and IL-4–
mediated effects. METHODS: Primary human fibroblasts were grown from endobronchial …
common receptor complex comprising IL-13 receptor α 1 (IL-13Rα1) and IL-4 receptor α (IL-
4Rα). The nonsignaling receptor IL-13 receptor α 2 (IL-13Rα2) binds IL-13 with high affinity
and specificity and is believed to be a decoy receptor for IL-13. OBJECTIVE: We sought to
examine the inhibitory effects of soluble and membrane-bound IL-13Rα2 on IL-13–and IL-4–
mediated effects. METHODS: Primary human fibroblasts were grown from endobronchial …
