ADAM33 and ADAM12 genetic polymorphisms and their expression in Egyptian children with asthma
SM Shalaby, RS Abdul-Maksoud… - Annals of Allergy …, 2016 - Elsevier
Background The ADAM family is involved in some pathologic processes, such as
inflammation and asthma. Objectives To assess the association between ADAM33 and
ADAM12 single-nucleotide polymorphisms (SNPs) with asthma risk and severity and to
investigate the effect of ADAM33 and ADAM12 polymorphisms on expression of these
proteases in sputum. Methods Two SNPs of the ADAM33 gene, F+ 1 (rs511898) G/A and
ST+ 4 (rs44707) A/C, and 2 SNPs of the ADAM12 gene, rs3740199 and rs1871054, were …
inflammation and asthma. Objectives To assess the association between ADAM33 and
ADAM12 single-nucleotide polymorphisms (SNPs) with asthma risk and severity and to
investigate the effect of ADAM33 and ADAM12 polymorphisms on expression of these
proteases in sputum. Methods Two SNPs of the ADAM33 gene, F+ 1 (rs511898) G/A and
ST+ 4 (rs44707) A/C, and 2 SNPs of the ADAM12 gene, rs3740199 and rs1871054, were …