The soluble form of a disintegrin and metalloprotease 33 promotes angiogenesis: implications for airway remodeling in asthma
I Puxeddu, YY Pang, A Harvey, HM Haitchi… - Journal of allergy and …, 2008 - Elsevier
BACKGROUND: A disintegrin and metalloprotease (ADAM)–33 is a susceptibility gene for
asthma and chronic obstructive pulmonary disease whose function remains unknown.
OBJECTIVE: Because asthmatic bronchoalveolar lavage fluid contains high levels of soluble
ADAM33 (sADAM33), which includes the catalytic domain, we postulated that its release
from cell membranes might play functional roles in airway remodeling by promoting
angiogenesis. METHODS: The proangiogenic activity of the highly purified catalytic domain …
asthma and chronic obstructive pulmonary disease whose function remains unknown.
OBJECTIVE: Because asthmatic bronchoalveolar lavage fluid contains high levels of soluble
ADAM33 (sADAM33), which includes the catalytic domain, we postulated that its release
from cell membranes might play functional roles in airway remodeling by promoting
angiogenesis. METHODS: The proangiogenic activity of the highly purified catalytic domain …
