[CITATION][C] ADAM-33 Surfaces as an Asthma Gene

SD Shapiro, CA Owen - New England Journal of Medicine, 2002 - Mass Medical Soc
New England Journal of Medicine, 2002Mass Medical Soc
A recent study identified ADAM-33 as an asthma gene. ADAMs are a subfamily of
metalloproteinases, originally identified as proteins on the cell surface, that have two
functional domains, a disintegrin and a metalloprotease domain (hence, the acronym
ADAM). The authors speculate on the ways in which an excess or deficiency of ADAM-33
could result in the expression of the asthma phenotype.
A recent study identified ADAM-33 as an asthma gene. ADAMs are a subfamily of metalloproteinases, originally identified as proteins on the cell surface, that have two functional domains, a disintegrin and a metalloprotease domain (hence, the acronym ADAM). The authors speculate on the ways in which an excess or deficiency of ADAM-33 could result in the expression of the asthma phenotype.
The New England Journal Of Medicine