Increased airway smooth muscle in preschool wheezers who have asthma at school age
R O'Reilly, N Ullmann, S Irving, CJ Bossley… - Journal of Allergy and …, 2013 - Elsevier
BACKGROUND: Increased airway smooth muscle (ASM) is a feature of established asthma
in schoolchildren, but nothing is known about ASM in preschool wheezers. OBJECTIVE: We
sought to determine endobronchial biopsy specimen ASM area fraction in preschool
wheezers and its association with asthma at school age. METHODS: ASM area, reticular
basement membrane thickness, and mucosal eosinophil and ASM mast cell values were
quantified in endobronchial biopsy specimens previously obtained from preschool children …
in schoolchildren, but nothing is known about ASM in preschool wheezers. OBJECTIVE: We
sought to determine endobronchial biopsy specimen ASM area fraction in preschool
wheezers and its association with asthma at school age. METHODS: ASM area, reticular
basement membrane thickness, and mucosal eosinophil and ASM mast cell values were
quantified in endobronchial biopsy specimens previously obtained from preschool children …
