The protective epithelial barrier in our skin undergoes constant regulation, whereby the
balance between differentiation and proliferation of keratinocytes plays a major role.
Impaired keratinocyte differentiation and proliferation are key elements in the
pathophysiology of several important dermatological diseases, including atopic dermatitis
and psoriasis. Ca 2+ influx plays an essential role in this process presumably mediated by
different transient receptor potential (TRP) channels. However, investigating their individual …