Activation of dendritic cells: translating innate into adaptive immunity
CR e Sousa - Current opinion in immunology, 2004 - Elsevier
Innate recognition of infection in vertebrates can lead to the induction of adaptive immune
responses through activation of dendritic cells (DCs). DCs are activated directly by
conserved pathogen molecules and indirectly by inflammatory mediators produced by other
cell types that recognise such molecules. In addition, it is likely that DCs are activated by
poorly characterised cellular stress molecules and by disturbances in the internal milieu.
The multiplicity of innate pathways for DC activation may have evolved to ensure that any …
responses through activation of dendritic cells (DCs). DCs are activated directly by
conserved pathogen molecules and indirectly by inflammatory mediators produced by other
cell types that recognise such molecules. In addition, it is likely that DCs are activated by
poorly characterised cellular stress molecules and by disturbances in the internal milieu.
The multiplicity of innate pathways for DC activation may have evolved to ensure that any …
Dendritic cells: translating innate to adaptive immunity
RM Steinman, H Hemmi - From innate immunity to immunological memory, 2006 - Springer
The innate immune system provides many ways to quickly resist infection. The twobest-
studieddefenses indendritic cells (DCs) are the productionof protective cytokines—like
interleukin (IL)-12 and type I interferons—and the activation and expansion of innate
lymphocytes. IL-12 and type I interferons influence distinct steps in the adaptive immune
response of lymphocytes, including the polarization of Thelper type 1 (Th1) CD4+ T cells,
thedevelopment of cytolytic T cells andmemory, and the antibody response. DCs havemany …
studieddefenses indendritic cells (DCs) are the productionof protective cytokines—like
interleukin (IL)-12 and type I interferons—and the activation and expansion of innate
lymphocytes. IL-12 and type I interferons influence distinct steps in the adaptive immune
response of lymphocytes, including the polarization of Thelper type 1 (Th1) CD4+ T cells,
thedevelopment of cytolytic T cells andmemory, and the antibody response. DCs havemany …