Humanized mouse model of mast cell–mediated passive cutaneous anaphylaxis and passive systemic anaphylaxis
Background Mast cells are a critical component of allergic responses in humans, and animal
models that allow the in vivo investigation of their contribution to allergy and evaluation of
new human-specific therapeutics are urgently needed. Objective To develop a new
humanized mouse model that supports human mast cell engraftment and human IgE-
dependent allergic responses. Methods This model is based on the NOD-scid IL2rg null
SCF/GM-CSF/IL3 (NSG-SGM3) strain of mice engrafted with human thymus, liver, and …
models that allow the in vivo investigation of their contribution to allergy and evaluation of
new human-specific therapeutics are urgently needed. Objective To develop a new
humanized mouse model that supports human mast cell engraftment and human IgE-
dependent allergic responses. Methods This model is based on the NOD-scid IL2rg null
SCF/GM-CSF/IL3 (NSG-SGM3) strain of mice engrafted with human thymus, liver, and …