Human mast cells present antigen to autologous CD4+ T cells
S Lotfi-Emran, BR Ward, QT Le, AL Pozez… - Journal of Allergy and …, 2018 - Elsevier
Background Mast cells (MCs), the primary effector cell of the atopic response, participate in
immune defense at host/environment interfaces, yet the mechanisms by which they interact
with CD4+ T cells has been controversial. Objective We used in situ–matured primary
human MCs and matched CD4+ T cells to diligently assess the ability of MCs to act as
antigen-presenting cells. Methods We examined mature human skin-derived MCs using flow
cytometry for expression of antigen-presenting molecules, for their ability to stimulate CD4+ …
immune defense at host/environment interfaces, yet the mechanisms by which they interact
with CD4+ T cells has been controversial. Objective We used in situ–matured primary
human MCs and matched CD4+ T cells to diligently assess the ability of MCs to act as
antigen-presenting cells. Methods We examined mature human skin-derived MCs using flow
cytometry for expression of antigen-presenting molecules, for their ability to stimulate CD4+ …