[HTML][HTML] Binding of activated α2-macroglobulin to its cell surface receptor GRP78 in 1-LN prostate cancer cells regulates PAK-2-dependent activation of LIMK
UK Misra, R Deedwania, SV Pizzo - Journal of Biological Chemistry, 2005 - ASBMB
Two characteristics of highly malignant cells are their increased motility and secretion of
proteinases allowing these cells to penetrate surrounding basement membranes and
metastasize. Activation of 21-kDa activated kinases (PAKs) is an important mechanism for
increasing cell motility. Recently, we reported that binding of receptor-recognized forms of
the proteinase inhibitor α 2-macroglobulin (α 2 M*) to GRP78 on the cell surface of 1-LN
human prostate cancer cells induces mitogenic signaling and cellular proliferation. In the …
proteinases allowing these cells to penetrate surrounding basement membranes and
metastasize. Activation of 21-kDa activated kinases (PAKs) is an important mechanism for
increasing cell motility. Recently, we reported that binding of receptor-recognized forms of
the proteinase inhibitor α 2-macroglobulin (α 2 M*) to GRP78 on the cell surface of 1-LN
human prostate cancer cells induces mitogenic signaling and cellular proliferation. In the …