Identification of a homologous heparin binding peptide sequence present in fibronectin and the 70 kDa family of heat-shock proteins
LK Hansen, JJ O'Leary, APN Skubitz, LT Furcht… - … et Biophysica Acta (BBA …, 1995 - Elsevier
This study was undertaken to characterize the potential heparin affinity of an amino-acid
sequence within the 70 kDa heat-shock family of proteins (HSPs) that shares homology with
a heparin-binding sequence present in the carboxy-terminus of fibronectin (FN), defined by
the synthetic peptide, FN-C/H-II (KNNQKSEPLIGRKKT). To first define the heparin binding
sequence within FN-C/H-II, solid phase binding assays were performed using overlapping,
short (7 amino acids) synthetic peptides corresponding to the amino-acid sequence within …
sequence within the 70 kDa heat-shock family of proteins (HSPs) that shares homology with
a heparin-binding sequence present in the carboxy-terminus of fibronectin (FN), defined by
the synthetic peptide, FN-C/H-II (KNNQKSEPLIGRKKT). To first define the heparin binding
sequence within FN-C/H-II, solid phase binding assays were performed using overlapping,
short (7 amino acids) synthetic peptides corresponding to the amino-acid sequence within …