[PDF][PDF] Bace2 is a β cell-enriched protease that regulates pancreatic β cell function and mass
D Esterhazy, I Stützer, H Wang, MP Rechsteiner… - Cell metabolism, 2011 - cell.com
D Esterhazy, I Stützer, H Wang, MP Rechsteiner, J Beauchamp, H Döbeli, H Hilpert, H Matile…
Cell metabolism, 2011•cell.comDecreased β cell mass and function are hallmarks of type 2 diabetes. Here we identified,
through a siRNA screen, beta site amyloid precursor protein cleaving enzyme 2 (Bace2) as
the sheddase of the proproliferative plasma membrane protein Tmem27 in murine and
human β cells. Mice with functionally inactive Bace2 and insulin-resistant mice treated with a
newly identified Bace2 inhibitor both display augmented β cell mass and improved control of
glucose homeostasis due to increased insulin levels. These results implicate Bace2 in the …
through a siRNA screen, beta site amyloid precursor protein cleaving enzyme 2 (Bace2) as
the sheddase of the proproliferative plasma membrane protein Tmem27 in murine and
human β cells. Mice with functionally inactive Bace2 and insulin-resistant mice treated with a
newly identified Bace2 inhibitor both display augmented β cell mass and improved control of
glucose homeostasis due to increased insulin levels. These results implicate Bace2 in the …
Summary
Decreased β cell mass and function are hallmarks of type 2 diabetes. Here we identified, through a siRNA screen, beta site amyloid precursor protein cleaving enzyme 2 (Bace2) as the sheddase of the proproliferative plasma membrane protein Tmem27 in murine and human β cells. Mice with functionally inactive Bace2 and insulin-resistant mice treated with a newly identified Bace2 inhibitor both display augmented β cell mass and improved control of glucose homeostasis due to increased insulin levels. These results implicate Bace2 in the control of β cell maintenance and provide a rational strategy to inhibit this protease for the expansion of functional pancreatic β cell mass.
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