Magnesium intake and risk of type 2 diabetes: meta-analysis of prospective cohort studies

JY Dong, P Xun, K He, LQ Qin - Diabetes care, 2011 - Am Diabetes Assoc
JY Dong, P Xun, K He, LQ Qin
Diabetes care, 2011Am Diabetes Assoc
OBJECTIVE Emerging epidemiological evidence suggests that higher magnesium intake
may reduce diabetes incidence. We aimed to examine the association between magnesium
intake and risk of type 2 diabetes by conducting a meta-analysis of prospective cohort
studies. RESEARCH DESIGN AND METHODS We conducted a PubMed database search
through January 2011 to identify prospective cohort studies of magnesium intake and risk of
type 2 diabetes. Reference lists of retrieved articles were also reviewed. A random-effects …
OBJECTIVE
Emerging epidemiological evidence suggests that higher magnesium intake may reduce diabetes incidence. We aimed to examine the association between magnesium intake and risk of type 2 diabetes by conducting a meta-analysis of prospective cohort studies.
RESEARCH DESIGN AND METHODS
We conducted a PubMed database search through January 2011 to identify prospective cohort studies of magnesium intake and risk of type 2 diabetes. Reference lists of retrieved articles were also reviewed. A random-effects model was used to compute the summary risk estimates.
RESULTS
Meta-analysis of 13 prospective cohort studies involving 536,318 participants and 24,516 cases detected a significant inverse association between magnesium intake and risk of type 2 diabetes (relative risk [RR] 0.78 [95% CI 0.73–0.84]). This association was not substantially modified by geographic region, follow-up length, sex, or family history of type 2 diabetes. A significant inverse association was observed in overweight (BMI ≥25 kg/m2) but not in normal-weight individuals (BMI <25 kg/m2), although test for interaction was not statistically significant (Pinteraction = 0.13). In the dose-response analysis, the summary RR of type 2 diabetes for every 100 mg/day increment in magnesium intake was 0.86 (95% CI 0.82–0.89). Sensitivity analyses restricted to studies with adjustment for cereal fiber intake yielded similar results. Little evidence of publication bias was observed.
CONCLUSIONS
This meta-analysis provides further evidence supporting that magnesium intake is significantly inversely associated with risk of type 2 diabetes in a dose-response manner.
Am Diabetes Assoc