Antibody treatment against pulmonary exposure to abrin confers significantly higher levels of protection than treatment against ricin intoxication
T Sabo, Y Gal, E Elhanany, A Sapoznikov, R Falach… - Toxicology Letters, 2015 - Elsevier
Abrin, a potent plant-derived toxin bearing strong resemblance to ricin, irreversibly
inactivates ribosomes by site-specific depurination, thereby precipitating cessation of protein
synthesis in cells. Due to its high availability and ease of preparation, abrin is considered a
biological threat, especially in context of bioterror warfare. To date, there is no established
therapeutic countermeasure against abrin intoxication. In the present study, we examined
the progress of pulmonary abrin intoxication in mice, evaluated the protective effect of …
inactivates ribosomes by site-specific depurination, thereby precipitating cessation of protein
synthesis in cells. Due to its high availability and ease of preparation, abrin is considered a
biological threat, especially in context of bioterror warfare. To date, there is no established
therapeutic countermeasure against abrin intoxication. In the present study, we examined
the progress of pulmonary abrin intoxication in mice, evaluated the protective effect of …