Quantitative profiling of the in vivo enzymatic activity of ricin reveals disparate depurination of different pulmonary cell types
R Falach, A Sapoznikov, Y Gal, O Israeli, M Leitner… - Toxicology letters, 2016 - Elsevier
The plant-derived toxins ricin and abrin, operate by site-specific depurination of ribosomes,
which in turn leads to protein synthesis arrest. The clinical manifestation following
pulmonary exposure to these toxins is that of a severe lung inflammation and respiratory
insufficiency. Deciphering the pathways mediating between the catalytic activity and the
developing lung inflammation, requires a quantitative appreciation of the catalytic activity of
the toxins, in-vivo. In the present study, we monitored truncated cDNA molecules which are …
which in turn leads to protein synthesis arrest. The clinical manifestation following
pulmonary exposure to these toxins is that of a severe lung inflammation and respiratory
insufficiency. Deciphering the pathways mediating between the catalytic activity and the
developing lung inflammation, requires a quantitative appreciation of the catalytic activity of
the toxins, in-vivo. In the present study, we monitored truncated cDNA molecules which are …