Chimeric plantibody passively protects mice against aerosolized ricin challenge
EK Sully, KJ Whaley, N Bohorova… - Clinical and Vaccine …, 2014 - Am Soc Microbiol
Clinical and Vaccine Immunology, 2014•Am Soc Microbiol
Recent incidents in the United States and abroad have heightened concerns about the use
of ricin toxin as a bioterrorism agent. In this study, we produced, using a robust plant-based
platform, four chimeric toxin-neutralizing monoclonal antibodies that were then evaluated for
the ability to passively protect mice from a lethal-dose ricin challenge. The most effective
antibody, c-PB10, was further evaluated in mice as a therapeutic following ricin exposure by
injection and inhalation.
of ricin toxin as a bioterrorism agent. In this study, we produced, using a robust plant-based
platform, four chimeric toxin-neutralizing monoclonal antibodies that were then evaluated for
the ability to passively protect mice from a lethal-dose ricin challenge. The most effective
antibody, c-PB10, was further evaluated in mice as a therapeutic following ricin exposure by
injection and inhalation.
Abstract
Recent incidents in the United States and abroad have heightened concerns about the use of ricin toxin as a bioterrorism agent. In this study, we produced, using a robust plant-based platform, four chimeric toxin-neutralizing monoclonal antibodies that were then evaluated for the ability to passively protect mice from a lethal-dose ricin challenge. The most effective antibody, c-PB10, was further evaluated in mice as a therapeutic following ricin exposure by injection and inhalation.
American Society for Microbiology