Extracting summary statistics to perform meta‐analyses of the published literature for survival endpoints

MKB Parmar, V Torri, L Stewart - Statistics in medicine, 1998 - Wiley Online Library
MKB Parmar, V Torri, L Stewart
Statistics in medicine, 1998Wiley Online Library
Meta‐analyses aim to provide a full and comprehensive summary of related studies which
have addressed a similar question. When the studies involve time to event (survival‐type)
data the most appropriate statistics to use are the log hazard ratio and its variance. However,
these are not always explicitly presented for each study. In this paper a number of methods
of extracting estimates of these statistics in a variety of situations are presented. Use of these
methods should improve the efficiency and reliability of meta‐analyses of the published …
Abstract
Meta‐analyses aim to provide a full and comprehensive summary of related studies which have addressed a similar question. When the studies involve time to event (survival‐type) data the most appropriate statistics to use are the log hazard ratio and its variance. However, these are not always explicitly presented for each study. In this paper a number of methods of extracting estimates of these statistics in a variety of situations are presented. Use of these methods should improve the efficiency and reliability of meta‐analyses of the published literature with survival‐type endpoints. © 1998 John Wiley & Sons, Ltd.
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