Bioenergetic failure of human peripheral blood monocytes in patients with septic shock is mediated by reduced F1Fo adenosine-5′-triphosphate synthase activity
AM Japiassu, APSA Santiago… - Critical care …, 2011 - journals.lww.com
Objective: Increasing evidence points to the role of mitochondrial dysfunction in the
pathogenesis of sepsis. Previous data indicate that mitochondrial function is affected in
monocytes from septic patients, but the underlying mechanisms and the impact of these
changes on the patients' outcome are unknown. We aimed to determine the mechanisms
involved in mitochondrial dysfunction in peripheral blood mononuclear cells from patients
with septic shock. Design: A cohort of patients with septic shock to study peripheral blood …
pathogenesis of sepsis. Previous data indicate that mitochondrial function is affected in
monocytes from septic patients, but the underlying mechanisms and the impact of these
changes on the patients' outcome are unknown. We aimed to determine the mechanisms
involved in mitochondrial dysfunction in peripheral blood mononuclear cells from patients
with septic shock. Design: A cohort of patients with septic shock to study peripheral blood …