[HTML][HTML] Histone H4-lysine 20 monomethylation is increased in promoter and coding regions of active genes and correlates with hyperacetylation
H Talasz, HH Lindner, B Sarg, W Helliger - Journal of Biological Chemistry, 2005 - ASBMB
Methylation and acetylation of position-specific lysine residues in the N-terminal tail of
histones H3 and H4 play an important role in regulating chromatin structure and function. In
the case of H3-Lys 4, H3-Lys 9, H3-Lys 27, and H4-Lys 20, the degree of methyla-tion was
variable from the mono-to the di-or trimethylated state, each of which was presumed to be
involved in the organization of chromatin and the activation or repression of genes. Here we
inves-tigated the interplay between histone H4-Lys 20 mono-and trim-ethylation and H4 …
histones H3 and H4 play an important role in regulating chromatin structure and function. In
the case of H3-Lys 4, H3-Lys 9, H3-Lys 27, and H4-Lys 20, the degree of methyla-tion was
variable from the mono-to the di-or trimethylated state, each of which was presumed to be
involved in the organization of chromatin and the activation or repression of genes. Here we
inves-tigated the interplay between histone H4-Lys 20 mono-and trim-ethylation and H4 …