[HTML][HTML] Catalytic function of the PR-Set7 histone H4 lysine 20 monomethyltransferase is essential for mitotic entry and genomic stability

SI Houston, KJ McManus, MM Adams, JK Sims… - Journal of biological …, 2008 - ASBMB
Histone-modifying enzymes play a critical role in modulating chromatin dynamics. In this
report we demonstrate that one of these enzymes, PR-Set7, and its corresponding histone
modification, the monomethylation of histone H4 lysine 20 (H4K20), display a distinct cell
cycle profile in mammalian cells: low at G 1, increased during late S phase and G 2, and
maximal from prometaphase to anaphase. The lack of PR-Set7 and monomethylated H4K20
resulted in a number of aberrant phenotypes in several different mammalian cell types …