Induction of nitric oxide synthase in subsets of murine pulmonary fibroblasts: effect on fibroblast interleukin-6 production
The purpose of this investigation was to determine whether mouse lung fibroblast subsets
have the ability to produce nitric oxide (NO), and if so, to characterize the induction and
effects of its synthesis. Previously, we isolated Thy1+ and Thy1-subpopulations of mouse
lung fibroblasts, which differ in terms of cytokine production, morphology, response to
cytokines and radiation, and ability to present antigen to T lymphocytes. When treated with
the proinflammatory cytokines IFN-γ, TNF-α, and IL-1α, these fibroblast lines produce …
have the ability to produce nitric oxide (NO), and if so, to characterize the induction and
effects of its synthesis. Previously, we isolated Thy1+ and Thy1-subpopulations of mouse
lung fibroblasts, which differ in terms of cytokine production, morphology, response to
cytokines and radiation, and ability to present antigen to T lymphocytes. When treated with
the proinflammatory cytokines IFN-γ, TNF-α, and IL-1α, these fibroblast lines produce …