Physiology of glucose homeostasis and insulin therapy in type 1 and type 2 diabetes
E Ferrannini - Endocrinology and Metabolism Clinics, 2012 - endo.theclinics.com
Glucose homeostasis is the maintenance of plasma glucose concentrations within a very
narrow band under most circumstances. In normal subjects, plasma glucose oscillations
rarely exceed 3 mmol/L (54 mg/dL), whereas lipid substrates, for example, free fatty acids
(FFA), can range up to 20-fold between a prolonged fast and the postcibal period. A tightly
homeostatic variable, such as eg, tissue perfusion pressure, requires a multiple, redundant
set of controls, and a coordinated deployment of primary and subsidiary mechanisms. In the …
narrow band under most circumstances. In normal subjects, plasma glucose oscillations
rarely exceed 3 mmol/L (54 mg/dL), whereas lipid substrates, for example, free fatty acids
(FFA), can range up to 20-fold between a prolonged fast and the postcibal period. A tightly
homeostatic variable, such as eg, tissue perfusion pressure, requires a multiple, redundant
set of controls, and a coordinated deployment of primary and subsidiary mechanisms. In the …