Effects of sodium DL-lactate on insulin secretion in anesthetized dogs

G Federspil, M Zaccaria, S Pedrazzoli, E Zago… - Diabetes, 1980 - Am Diabetes Assoc
G Federspil, M Zaccaria, S Pedrazzoli, E Zago, C DePalo, C Scandellari
Diabetes, 1980Am Diabetes Assoc
The effect of sodium DL-lactate administration on insulin release in anesthetized dogs has
been studied. Eleven mongrel dogs were infused with sodium DL-lactate for 20 min at the
rate of 20 mg/kg· min. Lactate infusion produced simultaneous increases in blood glucose
and plasma insulin levels in the pancreatico-duodenal vein. To determine whether lactate
stimulated insulin secretion directly, sodium DL-lactate was rapidly injected into the
pancreatic artery of six dogs; this pulse induced a significant increase in insulin release from …
The effect of sodium DL-lactate administration on insulin release in anesthetized dogs has been studied. Eleven mongrel dogs were infused with sodium DL-lactate for 20 min at the rate of 20 mg/kg · min. Lactate infusion produced simultaneous increases in blood glucose and plasma insulin levels in the pancreatico-duodenal vein. To determine whether lactate stimulated insulin secretion directly, sodium DL-lactate was rapidly injected into the pancreatic artery of six dogs; this pulse induced a significant increase in insulin release from pancreatic B-cells, even in the absence of a measurable change in blood glucose. Diazoxide, when infused in six dogs, blocked lactate-induced insulin secretion. These findings indicate that lactate, as do other circulating energy fuels, may play a role in the physiologic control of insulin secretion.
Am Diabetes Assoc