Dendritic cells (DCs) produce cytokines and are susceptible to cytokine-mediated activation.
Thus, interaction of resting immature DCs with TLR ligands, for example nucleic acids, or
with microbes leads to a cascade of pro-inflammatory cytokines and skewing of T cell
responses. Conversely, several cytokines are able to trigger DC activation (maturation) via
autocrine, for example TNF and plasmacytoid DCs, and paracrine, for example type I IFN
and myeloid DCs, pathways. By controlling DC activation, cytokines regulate immune …