Human T follicular helper cells: development and subsets

N Schmitt, H Ueno - Crossroads Between Innate and Adaptive Immunity IV, 2013 - Springer
N Schmitt, H Ueno
Crossroads Between Innate and Adaptive Immunity IV, 2013Springer
Antibody response constitutes one of the key immune protection mechanisms. T follicular
helper (Tfh) cells represent the major CD4+ T cell subset that provides help to B cells to
induce antibody response. How Tfh cells develop and how Tfh cells or their associated
subsets regulate antibody response in humans remains largely unknown. In this review, we
will summarize the recent discoveries on the biology of Tfh cells, with a particular focus on
human Tfh cells.
Abstract
Antibody response constitutes one of the key immune protection mechanisms. T follicular helper (Tfh) cells represent the major CD4+ T cell subset that provides help to B cells to induce antibody response. How Tfh cells develop and how Tfh cells or their associated subsets regulate antibody response in humans remains largely unknown. In this review, we will summarize the recent discoveries on the biology of Tfh cells, with a particular focus on human Tfh cells.
Springer