Defining the antigen-specific T-cell response to vaccination and poly (I: C)/TLR3 signaling: evidence of enhanced primary and memory CD8 T-cell responses and …
ML Salem, AN Kadima, DJ Cole… - Journal of …, 2005 - journals.lww.com
Abstract Poly (I: C), a synthetic double-stranded RNA polymer and a TLR3 agonist, can be
used as a vaccine adjuvant to enhance adaptive immunity. However, the antigen-specific
CD8 T-cell response to peptide vaccination and poly (I: C) has not been clearly defined.
Here, the authors characterized the antigen-specific CD8 T-cell response to peptide
vaccination and poly (I: C) and specifically addressed the hypothesis that poly (I: C) can
enhance antitumor immunity. To define the antigen-specific T-cell response, the authors …
used as a vaccine adjuvant to enhance adaptive immunity. However, the antigen-specific
CD8 T-cell response to peptide vaccination and poly (I: C) has not been clearly defined.
Here, the authors characterized the antigen-specific CD8 T-cell response to peptide
vaccination and poly (I: C) and specifically addressed the hypothesis that poly (I: C) can
enhance antitumor immunity. To define the antigen-specific T-cell response, the authors …