[HTML][HTML] Adipose-specific disruption of autotaxin enhances nutritional fattening and reduces plasma lysophosphatidic acid
R Dusaulcy, C Rancoule, S Grès, E Wanecq… - Journal of lipid …, 2011 - ASBMB
Autotaxin (ATX) is a secreted lysophospholipase D that generates the lipid mediator
lysophosphatidic acid (LPA). ATX is secreted by adipose tissue and its expression is
enhanced in obese/insulin-resistant individuals. Here, we analyzed the specific contribution
of adipose-ATX to fat expansion associated with nutritional obesity and its consequences on
plasma LPA levels. We established ATX F/F/aP2-Cre (FATX-KO) transgenic mice carrying a
null ATX allele specifically in adipose tissue. FATX-KO mice and their control littermates …
lysophosphatidic acid (LPA). ATX is secreted by adipose tissue and its expression is
enhanced in obese/insulin-resistant individuals. Here, we analyzed the specific contribution
of adipose-ATX to fat expansion associated with nutritional obesity and its consequences on
plasma LPA levels. We established ATX F/F/aP2-Cre (FATX-KO) transgenic mice carrying a
null ATX allele specifically in adipose tissue. FATX-KO mice and their control littermates …