[HTML][HTML] Primed CD8+ T-Cell Responses to AllogeneicEndothelial Cells Are Controlled by Local Complement Activation
H Raedler, M Yang, PN Lalli, ME Medof… - American Journal of …, 2009 - Elsevier
CD8 T cells primed by transplantation recognize allogeneic class I MHC molecules
expressed on graft vascular endothelium and contribute to allograft injury. We previously
showed that immune cell-derived complement activation fragments are integral to T cell
activation/expansion. Herein we tested the impact of local complement production/activation
on T cell/endothelial cell (EC) interactions. We found that proinflammatory cytokines
upregulated alternative pathway complement production by ECs, yielding C5a. We further …
expressed on graft vascular endothelium and contribute to allograft injury. We previously
showed that immune cell-derived complement activation fragments are integral to T cell
activation/expansion. Herein we tested the impact of local complement production/activation
on T cell/endothelial cell (EC) interactions. We found that proinflammatory cytokines
upregulated alternative pathway complement production by ECs, yielding C5a. We further …