[HTML][HTML] Immune cell-derived C3a and C5a costimulate human T cell alloimmunity
P Cravedi, J Leventhal, P Lakhani, SC Ward… - American Journal of …, 2013 - Elsevier
Emerging evidence indicates that complement provides costimulatory signals for murine T
cells but whether complement impacts human T cells remains unclear. We observed
production of complement activation products C3a and C5a during in vitro cultures of human
T cells responding to allogeneic dendritic cells (DC). Both partners expressed the receptors
for C3a (C3aR) and C5a (C5aR) and C3aR-and C5aR-antagonists inhibited T cell
proliferation. Recombinant C3a/C5a promoted CD4+ T cell expansion, bypassed the …
cells but whether complement impacts human T cells remains unclear. We observed
production of complement activation products C3a and C5a during in vitro cultures of human
T cells responding to allogeneic dendritic cells (DC). Both partners expressed the receptors
for C3a (C3aR) and C5a (C5aR) and C3aR-and C5aR-antagonists inhibited T cell
proliferation. Recombinant C3a/C5a promoted CD4+ T cell expansion, bypassed the …