Initial findings were obtained by JL and MEM and were published in abstract form. PSH and MEM jointly and interactively led and funded the project; designed the overall direction of the studies; analyzed, reviewed, and interpreted data; and wrote and edited the manuscript. J.-HS performed the majority of the experiments, analyzed and interpreted data, constructed the majority of the figures, and contributed to the writing and editing of the manuscript. MGS performed experiments and edited the manuscript. WZ and ZY performed the statistical analyses and interpretation of the microarray data, created the associated microarray figures, and contributed to editing of the manuscript.