Gelatinase B deficiency does not protect against lipopolysaccharide-induced acute lung injury
T Betsuyaku, JM Shipley, Z Liu, RM Senior - Chest, 1999 - journal.chestnet.org
B in acute lung injury, we studied mice containing a targeted deletion in the gelatinase B
gene. Following intratracheal instillation of lipopolysaccharide (LPS), we found that the lung
content of PMNs, as determined by myeloperoxidase activity, increased similarly in
gelatinase B-deficient and wild-type mice at 3, 6, and 12 h. In addition, BAL fluid contained
equivalent numbers of PMNs in both types of mice at 24 h. Alveolar permeability and
basement membrane injury were also similar in gelatinase B-deficient mice and wild-type …
gene. Following intratracheal instillation of lipopolysaccharide (LPS), we found that the lung
content of PMNs, as determined by myeloperoxidase activity, increased similarly in
gelatinase B-deficient and wild-type mice at 3, 6, and 12 h. In addition, BAL fluid contained
equivalent numbers of PMNs in both types of mice at 24 h. Alveolar permeability and
basement membrane injury were also similar in gelatinase B-deficient mice and wild-type …